Cytokines and diseases. Clinical applications of RhG-CSF.

rhG-CSF resistant neutropenia in SLE.

Action of granulopoiesis-stimulating cytokines rhG-CSF, rhGM-CSF, and rmGM-CSF on murine haematopoietic progenitor cells for granulocytes and macrophages (GM-CFC).

The aim of this study was to provide new data to the knowledge of mechanisms by which recombinant human granulocyte colony-stimulating factor (rhG-CSF), recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) enhance the numbers of colonies growing from hematopoietic progenitor cells for gra...

Comparison of two regimens of RhG-CSF in neutropenic neonatal septicemia: a randomized clinical trial.

Considering the 50% mortality rate of neonatal septicemia associated with neutropenia and increasing resistance to antibiotics, simultaneous antibiotic therapy strategies are becoming more important. However, few studies have been performed to evaluate effectiveness of RhG-CSF in the treatment of neutropenia in neonates. This randomized clinical trial was performed on 40 neutropenic neonates wi...

Long-term safety of filgrastim (rhG-CSF) administration

This journal recently included an article by Bennett et al (2006) reporting five cases of haematological malignancy occurring in normal individuals following exposure to haematopoietic growth factors. Three cases described lymphoid malignancies (non-Hodgkin lymphoma and chronic lymphocytic leukaemia) occurring months to years after receipt of an investigational agent (pegylated, recombinant meg...

comparison of two regimens of rhg-csf in neutropenic neonatal septicemia: a randomized clinical trial

considering the 50% mortality rate of neonatal septicemia associated with neutropenia and increasing resistance to antibiotics, simultaneous antibiotic therapy strategies are becoming more important. however, few studies have been performed to evaluate effectiveness of rhg-csf in the treatment of neutropenia in neonates. this randomized clinical trial was performed on 40 neutropenic neonates wi...